منابع مشابه
Dubin-Johnson syndrome.
A young man presented with recurrent episodes of mild jaundice. Apart from conjugated hyperbilirubinemia, other liver function tests were always normal. Clinical suspicion of Dubin-Johnson syndrome was raised. Liver biopsy showed diffuse deposition of coarse granular dark brown pigment in hepatocytes. Dubin-Johnson syndrome is a benign condition, which results from a hereditary defect in biliar...
متن کاملCholescintigraphy in Dubin-Johnson syndrome.
Hereditary or familial hiperbilirubinemia comprises a group of syndromes (Dubin-Johnson’s, Rotor’s, hepatic storage disease) in which hyperbilirubinemia, predominantly unconjugated or conjugated, occurs as an isolated biochemical abnormality without evidence of either hepatocellular necrosis or cholestasis. We present a patient with Dubin-Johnson syndrome, one of the familial disorders associat...
متن کاملDubin-Johnson syndrome presenting with neonatal cholestasis.
We report a case of Dubin-Johnson syndrome presenting with neonatal cholestasis. Liver histology was studied during the neonatal period and at 6 years of age. Distinct brownish pigment granules in hepatocytes were noted. This case confirms that Dubin-Johnson syndrome is a cause of neonatal cholestasis.
متن کاملDubin-Johnson syndrome in a Saudi neonate.
There are many disorders associated with direct hyperbilirubinemia in the neonatal period. These usually need urgent referral to identify treatable diseases. DubinJohnson Syndrome (DJS), which results from impaired hepatic excretory function, is an uncommon cause of neonatal jaundice and is only sporadically reported in neonates. We report here a neonate who presented with direct hyperbilirubin...
متن کاملLucey-Driscoll syndrome Secretion of Dubin-Johnson syndrome
Cholestasis may be defined as stagnation of bile within the intrahepatic or extrahepatic biliary tree. Biochemically, there is retention of conjugated bilirubin, bile salts, and alkaline phosphatase; morphologically, there is at least dilatation of biliary canaliculi and loss of their microvilli, and later accumulation of bile pigment in the canaliculi (bile plugs)."0 The mechanism underlying t...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1975
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)32436-9